Elena B. Pasquale

Automation of high-throughput workflow for arrayed CRISPR activation library screening

This paper develops an automated high-throughput workflow for arrayed CRISPRa screening, demonstrating its effectiveness in identifying growth reduction phenotypes in HEK293 cells.

Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role

The paper identifies frequent EPHA2 mutations in cholangiocarcinoma and shows they disrupt forward signaling, suggesting EPHA2 acts as a tumor suppressor.

Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HSNCC

This study shows that targeting the EphB4-ephrinB2 axis with engineered ligands reduces metastasis in HNSCC by modulating tumor microenvironment and immune responses.

The pro-tumoral and anti-tumoral roles of EphA4 on T regulatory cells and tumor associated macrophages during HNSCC tumor progression.

This study investigates the dual role of EphA4 in T regulatory cells and tumor-associated macrophages during HNSCC progression, showing pro-tumoral and anti-tumoral effects respectively.