Rondell Patrell Graham

CD4+ T cells promote fibrosis during metabolic dysfunction-associated steatohepatitis

This study identifies CD4+ T cells as drivers of fibrosis in MASH by showing their proinflammatory activity and the therapeutic potential of targeting the OX40L-OX40 axis.

Intestinal Stem Cells from Patients with Inflammatory Bowel Disease Retain an Epigenetic Memory of Inflammation

This study shows that intestinal stem cells from IBD patients retain epigenetic memory of inflammation, leading to heightened responses to future injury but also increased risk of relapse.

Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role

The paper identifies frequent EPHA2 mutations in cholangiocarcinoma and shows they disrupt forward signaling, suggesting EPHA2 acts as a tumor suppressor.

Role of Long Chain Acyl-CoA Synthetases in MASH-driven Hepatocellular Carcinoma and Ferroptosis

This study investigates the role of long chain acyl-CoA synthetases in MASH-HCC and ferroptosis, identifying ACSL4 as a key player in lipid metabolism and immune microenvironment.