Identification of RNA binding proteins that mediate a quality control mechanism of splicing
Maram Arafat, Valer Gotea, Mubarak Ishaq Umar, Aya Muharram, Eyal Kamhi, Reuven Agami, Joseph M. Sperling, Markus Hafner, Laura L. Elnitski, Ruth Sperling
The paper identifies RNA-binding proteins involved in suppressing latent splice site activation, with ALYREF interacting with U5 snRNA to regulate splicing accuracy.
bioRxiv · Jul 20, 2025 · PreprintGenomics