Author

Ruth Sperling

Hebrew University of JerusalemORCID 0000-0002-8950-4584Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Aya Muharram· 3 shared Maram ArafatiD· 3 shared Joseph M. SperlingiD· 2 shared Laura L. ElnitskiiD· 2 shared Valer GoteaiD· 2 shared Amir EdeniD· 1 shared Ayub BoulosiD· 1 shared Eyal Kamhi· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersGenomics

Aya Muharram

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Author profile →

3 papers

Recent·Most cited

Spliceosomal miR-99b Regulates SPACA6-AS1 Pre-mRNA Levels and Promotes Malignant Phenotypes in Breast Cancer

Aya Muharram, Maram Arafat, Michal Linial B, Ruth Sperling

This study identifies miR-99b's nuclear role in regulating SPACA6-AS1 pre-mRNA splicing and its contribution to breast cancer progression.

bioRxiv · Aug 20, 2026 · PreprintMolecular Biology

Identification of RNA binding proteins that mediate a quality control mechanism of splicing

Maram Arafat, Valer Gotea, Mubarak Ishaq Umar, Aya Muharram, Eyal Kamhi, Reuven Agami, Joseph M. Sperling, Markus Hafner, Laura L. Elnitski, Ruth Sperling

The paper identifies RNA-binding proteins involved in suppressing latent splice site activation, with ALYREF interacting with U5 snRNA to regulate splicing accuracy.

bioRxiv · Jul 20, 2025 · PreprintGenomics

A Novel Role for Nucleolin in Splice Site Selection

Kinneret Shefer, Ayub Boulos, Valer Gotea, Maram Arafat, Yair Ben-Chaim, Aya Muharram, Sara Isaac, Amir Eden, Joseph M. Sperling, Laura L. Elnitski, Ruth Sperling

This study identifies nucleolin as a novel regulator of splice site selection by directly interacting with initiator-tRNA, preventing latent splicing that would generate defective mRNAs.

RNA Biology · Feb 27, 2022Peer-reviewedGenomics