Author

Reuven Agami

The Netherlands Cancer InstituteORCID 0000-0002-2848-2473Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

Julien ChampagneiD· 2 shared Alexander KowariD· 1 shared Alexey I. NesvizhskiiiD· 1 shared Andres M. EliaiD· 1 shared Angelika Beate RiemeriD· 1 shared Ariel Galindo‐AlbarrániD· 1 shared Aya Muharram· 1 shared Daniela S. ThommeniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersSystems Biology

Julien ChampagneORCID

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Author profile →

3 papers

Recent·Most cited

MHC1-TIP enables single-tube multimodal immunopeptidome profiling and uncovers intratumoral heterogeneity in antigen presentation

Mayukha Bathini, Diana Bocaniciu, Fraser D. Johnson, Rick C.P. de Jong, Fengchao Yu, Vincenzo Davide Aloi, Marije C. Kuiken, Janniek R. Mors, Lisanne Giebel, Julien Champagne, Onno B. Bleijerveld, Reuven Agami, Krijn Kristian Dijkstra, Daniela S. Thommen, Alexey I. Nesvizhskii, Rik G.H. Lindeboom

Communications Biology · Jan 22, 2026Peer-reviewedSystems Biology

Upstream open reading frame translation enhances immunogenic peptide presentation in mitotically arrested cancer cells

Alexander Kowar, Jonas Philipp Becker, Rossella Del Pizzo, Zhiwei Tang, Julien Champagne, Kathrin Wellach, Kiana Samimi, Ariel Galindo‐Albarrán, Pierre-René Körner, Jasmine Montenegro Navarro, Andres M. Elia, Fiona Megan Tilghman, Hanan Sakeer, Marco Antonio Mendoza-Parra, Angelika Beate Riemer, , Fabricio Loayza‐Puch

The paper shows that mitotic arrest in cancer cells enhances uORF/uoORF translation, leading to increased immunopeptide presentation and T-cell mediated killing.

Nature Communications · Aug 27, 2025Peer-reviewedCancer Biology

Identification of RNA binding proteins that mediate a quality control mechanism of splicing

Maram Arafat, Valer Gotea, Mubarak Ishaq Umar, Aya Muharram, Eyal Kamhi, Reuven Agami, Joseph M. Sperling, Markus Hafner, Laura L. Elnitski, Ruth Sperling

The paper identifies RNA-binding proteins involved in suppressing latent splice site activation, with ALYREF interacting with U5 snRNA to regulate splicing accuracy.

bioRxiv · Jul 20, 2025 · PreprintGenomics