Author

Joseph M. Sperling

Weizmann Institute of ScienceORCID 0000-0003-1916-5633Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2

Frequent Co-Authors

Aya Muharram· 2 shared Laura L. ElnitskiiD· 2 shared Maram ArafatiD· 2 shared Ruth SperlingiD· 2 shared Valer GoteaiD· 2 shared Amir EdeniD· 1 shared Ayub BoulosiD· 1 shared Eyal Kamhi· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenomics

Aya Muharram

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintJul 20, 2025

Identification of RNA binding proteins that mediate a quality control mechanism of splicing

Maram Arafat, Valer Gotea, Mubarak Ishaq Umar…·Ruth Sperling

The paper identifies RNA-binding proteins involved in suppressing latent splice site activation, with ALYREF interacting with U5 snRNA to regulate splicing accuracy.

DOI 10.1101/2025.07.20.665773

humanbulk RNA-seq

𝕏 PostBluesky

GenomicsRNA BiologyPeer-reviewedFeb 27, 2022

A Novel Role for Nucleolin in Splice Site Selection

Kinneret Shefer, Ayub Boulos, Valer Gotea…·Ruth Sperling

This study identifies nucleolin as a novel regulator of splice site selection by directly interacting with initiator-tRNA, preventing latent splicing that would generate defective mRNAs.

10 citations

humanbulk RNA-seq

𝕏 PostBluesky