Excitatory: inhibitory imbalance in Alzheimer's disease is exacerbated by seizures with attenuation after rapamycin treatment in 5XFAD mice.
Aaron J Barbour, Sarah Gourmaud, E Lancaster, X Li, D Stewart, David John Irwin, Delia M. Talos, F E Jensen
The paper investigates E:I imbalance in AD patients and 5XFAD mice, showing seizures worsen it and rapamycin treatment can reverse some effects.
bioRxiv · Mar 2, 2023 · PreprintNeuroscience