Author

Aaron J Barbour

University of PennsylvaniaORCID 0000-0002-4880-6797Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 1 Assay:protein sequence· 1

Frequent Co-Authors

Delia M. TalosiD· 3 shared Frances E. JenseniD· 2 shared Keegan F. Hoag· 2 shared Abigail Chavez· 1 shared Alfredo LucasiD· 1 shared Chloe Hassman· 1 shared D Stewart· 1 shared David John IrwiniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersNeuroscience

Delia M. TalosORCID

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3 papers

Recent·Most cited

Seizures drive tau propagation in a tauopathy mouse model

Aaron J Barbour, Keegan F. Hoag, Virginia Lee, Delia M. Talos, Frances E. Jensen

This study shows that seizures worsen tau pathology in a tauopathy mouse model by promoting tau propagation in seizure-activated neurons.

bioRxiv · Mar 17, 2026 · PreprintNeuroscience

Hyperactive neuronal networks enhance tau spread in an Alzheimer's disease mouse model

Aaron J Barbour, Keegan F. Hoag, Eli J. Cornblath, Abigail Chavez, Alfredo Lucas, Xiaofan Li, Sydney E Zebrowitz, Chloe Hassman, Omar Vazquez, Sharon X. Xie, Edward B. Lee, Kathryn A. Davis, Virginia M.‐Y. Lee, Delia M. Talos, Frances E. Jensen

This study shows that neuronal hyperactivity and seizures increase tau spread in an Alzheimer's disease mouse model and correlate with memory deficits.

bioRxiv · Dec 1, 2024 · PreprintNeuroscience

Excitatory: inhibitory imbalance in Alzheimer's disease is exacerbated by seizures with attenuation after rapamycin treatment in 5XFAD mice.

Aaron J Barbour, Sarah Gourmaud, E Lancaster, X Li, D Stewart, David John Irwin, Delia M. Talos, F E Jensen

The paper investigates E:I imbalance in AD patients and 5XFAD mice, showing seizures worsen it and rapamycin treatment can reverse some effects.

bioRxiv · Mar 2, 2023 · PreprintNeuroscience