David John Irwin

Large-scale cerebrospinal fluid proteomics identifies diagnostic biomarker candidates across the clinico-pathological continuum of frontotemporal lobar degeneration

The paper identifies potential diagnostic biomarkers for frontotemporal lobar degeneration subtypes using cerebrospinal fluid proteomics.

Cerebrospinal fluid YWHAG:NPTX2 ratio predicts clinical severity and future phenoconversion in frontotemporal lobar degeneration

The paper identifies the CSF YWHAG:NPTX2 ratio as a biomarker for predicting clinical severity and phenoconversion in FTLD, showing strong correlation with disease progression and improved trial design potential.

Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neurodegenerative pathologies

The paper examines subcortical and limbic volume associations with cortical thinning and neurodegenerative pathologies in postmortem brain MRI data from multiple disease groups.

Microglial reactivity in the hippocampal CA2 is associated with advanced neuronal α-synucleinopathy

This study examines the association between microglial reactivity and neuronal α-synucleinopathy in specific hippocampal subfields in Lewy body disease patients.

Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo segmentation II

The paper characterizes hippocampal subfield border variability using postmortem MRI and histology, finding consistent subfield appearance/disappearance orders and no clear diagnosis-related differences.

Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing

This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.

Cytoarchitectonic gradients of laminar degeneration in behavioral variant frontotemporal dementia

This study examines laminar neurodegeneration patterns in bvFTD-tau and bvFTD-TDP, finding progressive SMI32-ir loss along a frontal cortical gradient in tau pathology.

α-Synuclein Conformations in Plasma Distinguish Parkinson's Disease from Dementia with Lewy Bodies

The paper identifies plasma α-synuclein conformations that distinguish Parkinson's disease from dementia with Lewy bodies and predict cognitive decline in PD.

Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories

This paper compares cytoarchitectonic delineations of medial temporal lobe subregions by four neuroanatomists, finding higher agreement in some areas and less in others.

Excitatory: inhibitory imbalance in Alzheimer's disease is exacerbated by seizures with attenuation after rapamycin treatment in 5XFAD mice.

The paper investigates E:I imbalance in AD patients and 5XFAD mice, showing seizures worsen it and rapamycin treatment can reverse some effects.

Genome-wide association study of autopsy-confirmed Multiple System Atrophy identifies common variants near ZIC1 and ZIC4

Joint ex vivo MRI and histology detect iron-rich cortical gliosis in Tau and TDP-43 proteinopathies

This study uses joint ex vivo MRI and histology to identify distinct iron-rich gliosis patterns in FTLD-Tau and FTLD-TDP, distinguishing them from other neurodegenerative conditions.

3D Mapping of Neurofibrillary Tangle Burden in the Human Medial Temporal Lobe

This study creates 3D maps of neurofibrillary tangle burden in the human medial temporal lobe using ex vivo MRI and dense histology, revealing variation along the anterior-posterior axis and widespread NFT distribution.

Integrating gene expression, spatial location and histology to identify spatial domains and spatially variable genes by graph convolutional network

This paper introduces SpaGCN, a graph convolutional network that identifies spatial domains and spatially variable genes by integrating gene expression, spatial location, and histology in spatial transcriptomics data.

Defining and predicting transdiagnostic categories of neurodegenerative disease

This paper defines transdiagnostic disease categories using histopathological data and predicts cluster membership from CSF and genotype data with high accuracy.

ATN status in amnestic and non-amnestic Alzheimer's disease and frontotemporal lobar degeneration

This paper evaluates the ATN framework's accuracy in diagnosing Alzheimer's disease subtypes and frontotemporal lobar degeneration using cerebrospinal fluid biomarkers, finding that non-amnestic Alzheimer's patients have lower tau levels and the framework is less sensitive to frontotemporal lobar degeneration.