Tauopathy primes co-filament assembly and dysfunction of TDP-43
Meghraj Singh Baghel, Grace D. Burns, Aswathy Peethambaran Mallika, Xiaoke K. Chen, F L Liu, Shruti Renganathan, Tong Li, Juan Carlos Troncoso, Philip C. Wong
This study shows that TDP-43 dysfunction accelerates tauopathy, which primes co-filament assembly and dysfunction of TDP-43, exacerbating neuron loss in AD-LATE.
bioRxiv · May 14, 2026 · PreprintNeuroscience