A functional interaction between TDP-43 and USP10 reveals USP10 dysfunction in TDP-43 proteinopathies
Alessandro Marrero‐Gagliardi, Judith Noda, Matteo Zanovello, G Gerenu, José Miguel Brito Armas, Alexander Bampton, Pascual Torres, Haizea Hernández-Eguiazu, S Moragón, F Pellegrini, C Pérez Hernández, Felipe Fumagallo-Reading, L Taoro-González, R Muñoz de Bustillo Alfaro, Anna‐Leigh Brown, , Abraham Acevedo‐Arozena
This study identifies a functional interaction between TDP-43 and USP10, showing USP10 modulates alternative splicing and can reduce TDP-43 toxicity in a mouse model of ALS and FTD.
bioRxiv · Jan 23, 2024 · PreprintNeuroscience