K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions
M. Lolicato, A. Natale, F. Aberemane-Ali, D. Crottes, S. Capponi, R. Duman, A. Wagner, J. M. Rosenberg, M. Grabe, D. L. Minor
This study identifies potassium-dependent conformational changes in K2P2.1 channels that underlie C-type gating, revealing asymmetric order-disorder transitions in the selectivity filter and adjacent loops.
bioRxiv · Mar 20, 2020Biophysics