Author

M. Lolicato

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. L. Minor· 4 shared C. Arrigoni· 2 shared A. A. Kossiakoff· 1 shared A. Magri· 1 shared A. Mondal· 1 shared A. Natale· 1 shared A. Renslo· 1 shared A. Rohaim· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersBiophysics

D. L. Minor

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Author profile →

5 papers

Recent·Most cited

VDAC1 selective molecules promote patients-derived cancer organoids death through mitochondrial-dependent metabolic interference

S. Conti Nibali, S. De Siervi, A. Magri, L. Brocca, S. Mantovani, B. Oliviero, M. U. Mondelli, V. De Pinto, C. Turato, C. Arrigoni, M. Lolicato

This paper identifies VA molecules that selectively target VDAC1 in cancer cells, causing mitochondrial distress and reduced viability, with less impact on healthy cells.

bioRxiv · Dec 4, 2023 · PreprintBiophysics

Development of covalent chemogenetic K2P channel activators

P. E. Deal, H. Lee, A. Mondal, M. Lolicato, P. R. Furtado de Mandonca, H. Black, X. El-Hilali, C. Bryant, E. Y. Isacoff, A. Renslo, D. L. Minor

This paper develops a chemogenetic method to irreversibly activate K2P channels, enabling studies of their function and potential therapeutic applications.

bioRxiv · Oct 15, 2023Biophysics

Quaternary structure independent folding of voltage-gated ion channel pore domain subunits

C. Arrigoni, M. Lolicato, D. Shaya, A. Rohaim, F. Findeisen, C. M. Colleran, P. Dominik, S. S. Kim, J. Schuermann, A. A. Kossiakoff, D. L. Minor

This paper shows that voltage-gated ion channel pore domains can maintain their structure without relying on quaternary interactions, revealing new insights into their folding and assembly.

bioRxiv · Aug 15, 2021Biophysics

K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions

M. Lolicato, A. Natale, F. Aberemane-Ali, D. Crottes, S. Capponi, R. Duman, A. Wagner, J. M. Rosenberg, M. Grabe, D. L. Minor

This study identifies potassium-dependent conformational changes in K2P2.1 channels that underlie C-type gating, revealing asymmetric order-disorder transitions in the selectivity filter and adjacent loops.

bioRxiv · Mar 20, 2020Biophysics

Polynuclear ruthenium amines inhibit K2P channels via a 'finger in the dam' mechanism

L. Pope, M. Lolicato, D. L. Minor

The paper shows RuR inhibits K2P channels by binding an acidic residue pair at a novel site, revealing a 'finger in the dam' mechanism and enabling design of super-responder K2Ps.

bioRxiv · Dec 4, 2019Biophysics