Author

D. L. Minor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:cryo-EM· 2 Assay:electrophysiology· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

M. Lolicato· 4 shared A. Mondal· 3 shared Z. Chen· 3 shared F. Abderemane-Ali· 2 shared J. Du Bois· 2 shared L. A. O'Connell· 2 shared A. A. Kossiakoff· 1 shared A. Alvarez-Buylla· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersBiophysics

M. Lolicato

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Author profile →

8 papers

Recent·Most cited

Development of covalent chemogenetic K2P channel activators

P. E. Deal, H. Lee, A. Mondal, M. Lolicato, P. R. Furtado de Mandonca, H. Black, X. El-Hilali, C. Bryant, E. Y. Isacoff, A. Renslo, D. L. Minor

This paper develops a chemogenetic method to irreversibly activate K2P channels, enabling studies of their function and potential therapeutic applications.

bioRxiv · Oct 15, 2023Biophysics

Structural basis for CaVα2δ:gabapentin binding

D. L. Minor, Z. Chen, A. Mondal

This study presents the cryo-EM structure of a gabapentin-bound calcium channel, revealing the binding pocket and explaining isoform selectivity.

bioRxiv · Dec 5, 2022Biophysics

EMC holdase:CaV1.2/CaVβ3 complex and CaV1.2 channel structures reveal CaV assembly and drug binding mechanisms

Z. Chen, A. Mondal, F. Abderemane-Ali, J. Montano, B. Zaro, D. L. Minor

The paper presents cryo-EM structures of CaV1.2 channels with auxiliary subunits and chaperones, revealing assembly mechanisms and drug binding sites.

bioRxiv · Oct 3, 2022Biophysics

Definition of a saxitoxin (STX) binding code enables discovery and characterization of the Anuran saxiphilin family

Z. Chen, S. Zakrzewska, H. S. Hajare, A. Alvarez-Buylla, F. Abderemane-Ali, M. Bogan, D. Ramirez, L. A. O'Connell, J. Du Bois, D. L. Minor

The paper defines the STX binding code for saxiphilin proteins and identifies new members of the Anuran saxiphilin family.

bioRxiv · Jun 9, 2022Biophysics

Quaternary structure independent folding of voltage-gated ion channel pore domain subunits

C. Arrigoni, M. Lolicato, D. Shaya, A. Rohaim, F. Findeisen, C. M. Colleran, P. Dominik, S. S. Kim, J. Schuermann, A. A. Kossiakoff, D. L. Minor

This paper shows that voltage-gated ion channel pore domains can maintain their structure without relying on quaternary interactions, revealing new insights into their folding and assembly.

bioRxiv · Aug 15, 2021Biophysics

Sodium channel toxin-resistance mutations do not govern batrachotoxin (BTX) autoresistance in poison birds and frogs

F. Abederemane-Ali, N. D. Rossen, M. E. Kobiela, R. A. Craig, C. E. Garrison, L. A. O'Connell, J. Du Bois, J. P. Dumbacher, D. L. Minor

The paper shows that Nav mutations are not responsible for BTX resistance in poison frogs and birds, suggesting alternative mechanisms like toxin sequestration.

bioRxiv · Oct 29, 2020Biophysics

K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions

M. Lolicato, A. Natale, F. Aberemane-Ali, D. Crottes, S. Capponi, R. Duman, A. Wagner, J. M. Rosenberg, M. Grabe, D. L. Minor

This study identifies potassium-dependent conformational changes in K2P2.1 channels that underlie C-type gating, revealing asymmetric order-disorder transitions in the selectivity filter and adjacent loops.

bioRxiv · Mar 20, 2020Biophysics

Polynuclear ruthenium amines inhibit K2P channels via a 'finger in the dam' mechanism

L. Pope, M. Lolicato, D. L. Minor

The paper shows RuR inhibits K2P channels by binding an acidic residue pair at a novel site, revealing a 'finger in the dam' mechanism and enabling design of super-responder K2Ps.

bioRxiv · Dec 4, 2019Biophysics