Long-term efficacy of adoptive cell therapy is determined by host CD8+ T cells and undermined by lymphodepleting preconditioning
D. Figueroa, J. P. Vega, A. Hernandez-Oliveras, F. Galvez-Cancino, F. Ardiles, F. Flores, S. Hidalgo, X. Lopez, H. Gonzalez, F. Osorio, V. Borgna, A. Lladser
This study shows that host CD8+ T cells enhance adoptive cell therapy (ACT) efficacy against melanoma, while lymphodepleting preconditioning reduces long-term effectiveness by impairing host immunity.
bioRxiv · May 16, 2024 · PreprintImmunology