X. Lopez

Long-term efficacy of adoptive cell therapy is determined by host CD8+ T cells and undermined by lymphodepleting preconditioning

This study shows that host CD8+ T cells enhance adoptive cell therapy (ACT) efficacy against melanoma, while lymphodepleting preconditioning reduces long-term effectiveness by impairing host immunity.

Atomistic molecular simulations of Aβ-Zn conformational ensembles

This study generates accurate force fields for Aβ-Zn complexes using molecular dynamics and Bayesian optimization, revealing more heterogeneous conformational ensembles than existing NMR models.

Markov state models from hierarchical density-based assignment

This paper introduces a modified workflow for building Markov state models using hierarchical density-based clustering to improve the accuracy and efficiency of conformational transition analysis in molecular dynamics simulations.