Author

F. De Marchis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

F. De Leo· 3 shared G. Musco· 3 shared G. Quilici· 2 shared M. E. Bianchi· 2 shared A. Gori· 1 shared A. Preti· 1 shared C. Zucchelli· 1 shared G. Giachin· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

F. De Leo

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3 papers

Recent·Most cited

The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with chemokine CXCL12

M. V. Mantonico, F. De Leo, G. Quilici, L. Colley, F. De Marchis, M. Crippa, T. Schulte, C. Zucchelli, S. Ricagno, G. Giachin, m. ghitti, M. E. Bianchi, G. Musco

This study identifies the acidic intrinsically disordered region of HMGB1 as critical for forming a dynamic fuzzy heterocomplex with CXCL12, which enhances inflammatory signaling through CXCR4.

bioRxiv · Jun 6, 2023Biochemistry

Discovery of 5,5'-methylenedi-2,3-cresotic acid as a potent inhibitor of the HMGB1/CXCL12 heterocomplex using Virtual Screening and NMR validation

F. De Leo, Q. Giacomo, F. De Marchis, M. V. Malisa, M. E. Bianchi, G. Musco

bioRxiv · Aug 25, 2020Biochemistry

Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment

F. De Leo, G. Quilici, M. Tirone, V. Mannella, F. De Marchis, A. Preti, A. Gori, M. Casalgrandi, R. Mezzapelle, M. Bianchi, G. Musco

This study shows Diflunisal inhibits HMGB1-mediated immune cell recruitment by disrupting the HMGB1/CXCL12 heterocomplex without affecting TLR4-dependent responses.

bioRxiv · Mar 1, 2019Biochemistry