A receptor tyrosine kinase regulated by the transcription factor VAB-3/PAX6 pairs with a pseudokinase to trigger immune signalling upon oomycete recognition in C. elegans
F. Drury, M. Grover, M. Hintze, J. Saunders, M. K. Fasseas, C. Constantinou, M. Barkoulas
This study identifies receptor tyrosine kinase OLD-1 and pseudokinase FLOR-1 as key components of oomycete recognition in C. elegans, regulated by VAB-3/PAX-6 and forming a genetic cluster with chil genes.
bioRxiv · Dec 15, 2022 · PreprintImmunology