Hierarchal single-cell lineage tracing reveals differential fate commitment of CD8 T-cell clones in response to acute infection.
L. Abdullah, F. E. Emiliani, C. M. Vaidya, H. Stuart, F. W. Kolling, M. E. Ackerman, L. Song, A. McKenna, Y. H. Huang
This study uses single-cell lineage tracing to show that CD8 T-cell clones exhibit differential fate commitment during acute infection, with some clones adopting memory or effector biases over time.
bioRxiv · Mar 21, 2024 · PreprintImmunology