Author

M. E. Ackerman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 5 Research Focus:cell type annotation· 4 Research Focus:clustering· 3 Organism:human· 3 Assay:proteomics· 3 Approach:deep learning· 2

Frequent Co-Authors

A. B. Balazs· 2 shared A. P. Hederman· 2 shared C. R. Garland· 2 shared D. A. Leib· 2 shared I. M. Backes· 2 shared J. Lee· 2 shared L. M. Walker· 2 shared N. C. Curtis· 2 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

A. B. Balazs

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Hierarchal single-cell lineage tracing reveals differential fate commitment of CD8 T-cell clones in response to acute infection.

L. Abdullah, F. E. Emiliani, C. M. Vaidya, H. Stuart, F. W. Kolling, M. E. Ackerman, L. Song, A. McKenna, Y. H. Huang

This study uses single-cell lineage tracing to show that CD8 T-cell clones exhibit differential fate commitment during acute infection, with some clones adopting memory or effector biases over time.

bioRxiv · Mar 21, 2024 · PreprintImmunology

Sex and species associated differences in Complement-mediated immunity in Humans and Rhesus macaques

N. S. Kelkar, B. S. Goldberg, J. Dufloo, T. Bruel, O. Schwartz, A. J. Hessell, M. E. Ackerman

This study compares complement-mediated immunity differences between humans and rhesus macaques, finding sex-based variations in humans and species-specific differences in complement activity.

bioRxiv · Oct 23, 2023Immunology

Characteristics and functions of infection-enhancing antibodies to the N-terminal domain of SARS-CoV-2

R. I. Connor, M. I. Sakharkar, C. G. Rappazzo, C. I. Kaku, N. C. Curtis, S. Shin, W. F. Wieland-Alter, J. A. Weiner, M. E. Ackerman, L. M. Walker, J. Lee, P. F. Wright

This study identifies infection-enhancing antibodies targeting the N-terminal domain of SARS-CoV-2 spike protein, which persist in convalescent patients and may be counteracted by viral mutations.

bioRxiv · Sep 19, 2023Immunology

Characterization of SARS-CoV-2 Convalescent Patients' Serological Repertoire Reveals High Prevalence of Iso-RBD Antibodies

N. C. Curtis, S. Shin, A. P. Hederman, R. I. Connor, W. F. Wieland-Alter, S. Ionov, J. Boylston, J. Rose, M. Sakharkar, D. B. Dorman, J. A. Dessaint, L. L. Gwilt, A. R. Crowley, J. Feldman, B. M. Hauser, , J. Lee

This study characterizes the serological repertoire of SARS-CoV-2 convalescent patients, revealing a high prevalence of iso-RBD antibodies that do not recognize prefusion-stabilized S, and shows that vaccination with prefusion-stabilized S reduces their prevalence.

bioRxiv · Sep 8, 2023 · PreprintImmunology

Antibody effector functions are required for broad and potent protection of neonates from herpes simplex virus infection

M. D. Slein, I. M. Backes, C. R. Garland, N. S. Kelkar, D. A. Leib, M. E. Ackerman

This study shows that both neutralization and effector functions of antibodies are needed for effective protection against neonatal HSV-1, while effector functions alone suffice for HSV-2.

bioRxiv · Aug 29, 2023 · PreprintImmunology

Maternally transferred monoclonal antibodies protect neonatal mice from herpes simplex virus-induced mortality and morbidity

I. M. Backes, B. K. Byrd, C. D. Patel, S. A. Taylor, C. R. Garland, S. W. MacDonald, A. B. Balazs, S. C. Davis, M. E. Ackerman, D. A. Leib

This study shows that HSV-specific monoclonal antibodies transferred from mothers or directly administered to neonatal mice reduce HSV-induced mortality and morbidity.

Journal of Experimental Medicine · Sep 26, 2022Peer-reviewedImmunology

Antibody-mediated prevention of vaginal HIV transmission is dictated by IgG subclass in humanized mice

J. M. Brady, M. Phelps, S. W. MacDonald, E. C. Lam, A. Nitido, D. Parsons, C. L. Boutros, C. E. Deal, S. Tanno, H. Natarajan, M. E. Ackerman, V. D. Vrbanac, A. B. Balazs

The paper investigates the role of IgG subclasses in HIV prevention using humanized mice, finding that VRC07-IgG1 provides substantial protection despite low concentrations.

bioRxiv · Jul 7, 2022Immunology

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities

Y. Chen, L. Sun, I. Ullah, G. Beaudoin-Bussieres, S. P. Anand, A. P. Hederman, W. D. Tolbert, R. Sherburn, D. N. Nguyen, L. Marchitto, S. Ding, D. Wu, Y. Luo, S. Gottumukkala, S. Moran, , M. Pazgier

The paper develops ACE2-Fc molecules that neutralize SARS-CoV-2 and show Fc-effector activity, effectively treating lethal infection in mice.

bioRxiv · Nov 24, 2021Microbiology