ImmunoPET as Stoichiometric Sensor for Glypican-3 in Models of Hepatocellular Carcinoma
O. J. Kelada, N. T. Gutsche, M. Bell, R. M. Berman, K. E. Baidoo, B. M. Warner, L. P. Szajek, J. Hong, M. Ho, P. L. Choyke, F. E. Escorcia
This paper demonstrates that the immunoPET agent [89Zr]Zr-DFO-TAB-H14 specifically and stoichiometrically binds to GPC3 in human liver cancer models, serving as a potential in vivo sensor for HCC diagnosis and therapy selection.
bioRxiv · Jan 31, 2020Cancer Biology