M. Ho

Tumor-Associated Macrophages Expand Chemoresistant, Ovarian Cancer Stem-Like Cells

This study shows that tumor-associated macrophages (TAMs) enhance ovarian cancer stem-like cell (OvCSC) proliferation and survival, contributing to chemotherapy resistance and relapse.

Monitoring Non-Specific Adsorption at Solid-Liquid Interfaces by Supercritical Angle Fluorescence Microscopy

This paper extends supercritical angle fluorescence microscopy to monitor dynamic surface phenomena by adding hardware and software, demonstrating its use in tracking non-specific adsorption of proteins and surfactants.

Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of Vulnerability

This paper develops a prefusion-stabilized Lassa virus GPC, identifies a neutralizing nanobody, and reveals a cleavage-dependent site of vulnerability at the trimer apex.

Camel nanobodies broadly neutralize SARS-CoV-2 variants

The paper isolates two camel nanobodies that broadly neutralize SARS-CoV-2 and its variants, showing therapeutic potential in mice.

A novel PD-L1-targeted shark VNAR single domain-based CAR-T strategy for treating breast cancer and liver cancer

This paper develops a PD-L1-targeted shark VNAR-based CAR-T strategy that effectively targets breast and liver cancer cells and reduces tumor metastasis in mice.

Dependable Algorithm for Visualizing Snoring Duration through Acoustic Analysis

The paper develops an algorithm to visualize snoring duration through acoustic analysis, showing higher reproducibility with digital recordings than a smartphone app.

Specialization and selective social attention establishes the balance between individual and social learning

The paper investigates how individuals balance individual and social learning in a virtual foraging environment by analyzing specialization and selective social attention.

Vegetation and Microbes Interact to Preserve Organic Matter in Wooded Peatlands

The paper investigates how vegetation and microbes interact to preserve organic matter in wooded peatlands, finding that slow-growing microbes and plant-induced recalcitrant carbon reduce carbon loss despite climate stressors.

ImmunoPET as Stoichiometric Sensor for Glypican-3 in Models of Hepatocellular Carcinoma

This paper demonstrates that the immunoPET agent [89Zr]Zr-DFO-TAB-H14 specifically and stoichiometrically binds to GPC3 in human liver cancer models, serving as a potential in vivo sensor for HCC diagnosis and therapy selection.

Transcriptomically-guided mesendoderm induction of human pluripotent stem cells using a systematically defined culture scheme

This study introduces a method using single-cell seeding and BMP4/Activin A treatment to induce mesendoderm from hPSCs, showing increased mesoderm and endoderm formation.