Author

F. E. Kemmerich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:DNA methylation· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

I. Songailiene· 2 shared M. Rutkauskas· 2 shared R. Seidel· 2 shared T. Sinkunas· 2 shared V. Siksnys· 2 shared D. J. Kauert· 1 shared J. Madariaga-Marcos· 1 shared P. Aldag· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

I. Songailiene

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2 papers

Recent·Most cited

Dynamic interplay between target search and recognition for the Cascade surveillance complex of type I-E CRISPR-Cas systems

P. Aldag, M. Rutkauskas, J. Madariaga-Marcos, I. Songailiene, T. Sinkunas, F. E. Kemmerich, D. J. Kauert, V. Siksnys, R. Seidel

This study investigates how the Type I-E CRISPR-Cas Cascade complex searches and recognizes DNA targets, showing that recognition probabilities are low and increased by DNA supercoiling and limited 1D diffusion.

bioRxiv · Dec 18, 2022Biophysics

A quantitative model for the dynamics of target recognition and off-target rejection by the CRISPR-Cas Cascade complex

M. Rutkauskas, I. Songailiene, P. Irmisch, F. E. Kemmerich, T. Sinkunas, V. Siksnys, R. Seidel

The paper develops a quantitative model to predict CRISPR-Cas Cascade off-target recognition dynamics using single-molecule experiments and shows it accurately captures target recognition with mutations.

bioRxiv · Jan 26, 2022 · PreprintBiophysics