Constitutive Inhibition of Transient Receptor Potential CanonicalType 6 (TRPC6) by O-GlcNAcylation at Threonine-221
D. A. Kass, S. Mishra, J. Ma, M. Sasaki, F. Farinelli, R. C. Page, M. J. Ranek, N. Zachara
This study identifies O-GlcNAcylation at Thr221 as a constitutive inhibitor of TRPC6 channel conductance and NFAT signaling, showing its conservation and functional importance across TRPC family members.
bioRxiv · Jun 15, 2022 · PreprintBiochemistry