Author

M. J. Ranek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. A. Kass· 3 shared B. L. Dunkerly-Eyring· 2 shared S. Mishra· 2 shared C. Patel· 1 shared C. U. Oeing· 1 shared D. B. Henderson· 1 shared D. McKoy· 1 shared F. Farinelli· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

D. A. Kass

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Signaling Node at TSC2 S1365 Potently Regulates T-Cell Differentiation and Improves Adoptive Cellular Cancer Therapy

D. A. Kass, J. D. Powell, C. Patel, Y. Dong, B. L. Dunkerly-Eyring, J. Wen, M. J. Ranek, L. M. Bartle, D. B. Henderson, J. Sagert

This study shows that mutating TSC2 at S1365 enhances T-cell effector function and memory formation, improving adoptive T-cell therapy for cancer.

bioRxiv · Nov 30, 2022 · PreprintImmunology

Constitutive Inhibition of Transient Receptor Potential CanonicalType 6 (TRPC6) by O-GlcNAcylation at Threonine-221

D. A. Kass, S. Mishra, J. Ma, M. Sasaki, F. Farinelli, R. C. Page, M. J. Ranek, N. Zachara

This study identifies O-GlcNAcylation at Thr221 as a constitutive inhibitor of TRPC6 channel conductance and NFAT signaling, showing its conservation and functional importance across TRPC family members.

bioRxiv · Jun 15, 2022 · PreprintBiochemistry

Single Serine on TSC2 Exerts Biased Control over mTORC1 Activation by ERK1/2 but Not Akt

B. L. Dunkerly-Eyring, M. Pinilla-Vera, D. McKoy, S. Mishra, M. I. Grajeda Martinez, C. U. Oeing, M. J. Ranek, D. A. Kass

The paper shows that a single serine on TSC2 selectively controls mTORC1 activation by ERK1/2 but not Akt, with implications for pathological versus physiological mTOR signaling.

bioRxiv · Jul 13, 2021 · PreprintCell Biology