Author

R. C. Page

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Animal Behavior & Cognition· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. C. Nix· 2 shared A. Bergstrom· 1 shared A. Katko· 1 shared A. R. Cupo· 1 shared A. R. de Silva· 1 shared A. W. Kao· 1 shared C. Bethel· 1 shared C. M. Nadel· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

J. C. Nix

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Author profile →

5 papers

Recent·Most cited

Visualizing Mitochondrial Heme Flow through GAPDH to Targets in Living Cells and its Regulation by NO

P. Biswas, J. Palazzo, S. Schlanger, D. T. Jayaram, S. Islam, R. C. Page, D. J. Stuehr

The paper visualizes mitochondrial heme flow through GAPDH to IDO1 in living cells and shows NO regulates heme reallocation between GAPDH and IDO1 based on NO levels.

bioRxiv · Jan 10, 2024 · PreprintCell Biology

Interaction with the membrane-anchored protein CHIC2 constrains the ubiquitin ligase activity of CHIP

M. D. Callahan, M. Hodul, E. C. Carroll, M. Ravalin, C. M. Nadel, A. R. de Silva, A. R. Cupo, L. E. McDermott, J. C. Nix, R. C. Page, A. W. Kao, J. E. Gestwicki

This study identifies CHIC2 as a chaperone-independent regulator of CHIP, showing it attenuates CHIP's ubiquitin ligase activity and contributes to neurodegeneration in C. elegans.

bioRxiv · Jul 17, 2023 · PreprintBiochemistry

Constitutive Inhibition of Transient Receptor Potential CanonicalType 6 (TRPC6) by O-GlcNAcylation at Threonine-221

D. A. Kass, S. Mishra, J. Ma, M. Sasaki, F. Farinelli, R. C. Page, M. J. Ranek, N. Zachara

This study identifies O-GlcNAcylation at Thr221 as a constitutive inhibitor of TRPC6 channel conductance and NFAT signaling, showing its conservation and functional importance across TRPC family members.

bioRxiv · Jun 15, 2022 · PreprintBiochemistry

A non-canonical metal center drives activity of the Sediminispirochaeta smaragdinae metallo-β- lactamase SPS-1

Z. Cheng, J. VanPelt, A. Bergstrom, C. Bethel, A. Katko, C. Miller, K. Mason, E. Cumming, H. Zhang, R. Kimble, S. Fullington, S. L. Bretz, J. C. Nix, R. A. Bonomo, D. L. Tierney, , M. W. Crowder

This study characterizes the metallo-β-lactamase SPS-1 from Sediminispirochaeta smaragdinae, revealing a novel metal binding site that challenges inhibitor design.

bioRxiv · Jun 2, 2018Biochemistry

Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of cerebellar CHIPopathy

C.-h. Shi, C. Rubel, S. E. Soss, R. Sanchez-Hodge, S. Zhang, D. A. Stevens, H. McDonough, R. C. Page, W. Chazin, C. Patterson, C.-y. Mao, M. S. Willis, H.-Y. Luo, M.-b. Tang, P. Du, , J. Schisler

This study investigates the effects of a CHIP mutation in preclinical models, showing it causes structural disruption and functional loss linked to motor and cognitive deficits.

bioRxiv · Mar 15, 2018Animal Behavior & Cognition