Palbociclib interferes with replication origin firing in a pRb independent manner
S.-J. Kim, C. Maric, l.-m. Briu, F. Fauchereau, G. Baldacci, M. Debatisse, S. KOUNDRIOUKOFF, J. C. cadoret
This paper shows palbociclib disrupts DNA replication in pRb-deficient cells by reducing origin firing and pre-initiation complex loading, leading to replicative stress and decreased cell viability.
bioRxiv · Sep 21, 2022 · PreprintCancer Biology