Leukotrienes promote stem cell self-renewal and chemoresistance in acute myeloid leukemia
C. Y. Park, A. W. Stranahan, I. Berezniuk, S. Chakraborty, F. Feller, M. Khalaj
This study identifies ALOX5 as a mediator of chemoresistance in AML by promoting LSC self-renewal through LTB4-BLTR signaling, suggesting ALOX5 inhibition could enhance chemotherapy efficacy.
bioRxiv · Feb 7, 2022 · PreprintCancer Biology