Author

C. Y. Park

Memorial Sloan Kettering Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Biochemistry· 2 Biophysics· 2 Cell Biology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 12 Organism:human· 11 Research Focus:cell type annotation· 7 Research Focus:cell signaling & trafficking· 5 Assay:bulk RNA-seq· 4 Organism:mouse· 4 Approach:statistical model· 4 Research Focus:cancer & tumor microenvironment· 3

Frequent Co-Authors

J. J. Fredberg· 3 shared I. Berezniuk· 2 shared J. A. Mitchel· 2 shared J. H. Kim· 2 shared J. P. Butler· 2 shared S. He· 2 shared A. Boppana· 1 shared A. D. Corrado· 1 shared

Activity by Year

2018-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersBiophysics

J. J. Fredberg

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Author profile →

14 papers

Recent·Most cited

Ecological determinants of disease and immunity in myelodysplastic syndromes

Robert F. Stanley, Beatrice D. Zhang, Kimon V. Argyropoulos, P Zhang, Maxim I. Maron, Brianna Gipson, C. Y. Park, Kenyon Weis, Alexander M. Lewis, Zoe Katsamakis, Charlotte Wishnack, Maria Adriana Cuibus, Ning Fan, Karen Zhao, Kenton Wu, , Susan DeWolf

This study uses spatial transcriptomics and single-cell analysis to reveal how MDS bone marrow microenvironments are altered, showing TGFβ dysregulation in malignant cells and immune escape mechanisms.

bioRxiv · May 9, 2026 · PreprintCancer Biology

The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability

N. Ravn-Boess, N. Roy, T. Hattori, D. Bready, H. Donaldson, C. Lawson, C. Lapierre, A. Korman, T. Rodrick, E. Liu, J. D. Frenster, G. Stephan, J. Wilcox, A. D. Corrado, J. Cai, , D. G. Placantonakis

This study identifies CD97 as a targetable vulnerability in glioblastoma through its role in tumor metabolism and signaling, supported by transcriptomic, proteomic, and functional analyses.

Cell Reports · Nov 1, 2023Peer-reviewedCancer Biology

Single-cell transcriptome dataset of human and mouse in vitro adipogenesis models

J. Li, C. Jin, S. Gustafsson, A. Rao, M. Wabitsch, C. Y. Park, T. Quertermous, E. Bielczyk-Maczynska, J. W. Knowles

The paper presents a single-cell RNA-sequencing dataset of human and mouse adipogenesis models, revealing three cell clusters during differentiation.

bioRxiv · Mar 27, 2023Cell Biology

The Human Mitochondrial Genome Encodes for an Interferon-Responsive Host Defense Peptide

M. C. Rice, M. Imun, S. W. Jung, C. Y. Park, J. S. Kim, R. W. Lai, C. R. Barr, J. M. Son, K. Tor, E. Kim, R. J. Lu, I. Cohen, B. A. Benayoun, C. Lee

This study identifies MOTS-c, a mitochondrial-encoded host defense peptide with antibacterial and immunomodulatory functions, showing that the immune system is encoded by both nuclear and mitochondrial genomes.

bioRxiv · Mar 2, 2023 · PreprintImmunology

CD99 Promotes Self-renewal in Hematopoietic Stem Cells and Leukemia Stem Cells by Regulating Protein Synthesis

Y. Huang, E. G. Kapti, Y. Ji, T. Thomas, J. Dempsey, K. Mims, I. Berezniuk, L. Guo, B. Kroger, W. Hu, C. Y. Park, S. S. Chung

This study shows CD99 regulates protein synthesis in hematopoietic stem cells and leukemia stem cells, promoting self-renewal and clonal expansion leading to AML.

bioRxiv · Feb 21, 2023Cancer Biology

Leukotrienes promote stem cell self-renewal and chemoresistance in acute myeloid leukemia

C. Y. Park, A. W. Stranahan, I. Berezniuk, S. Chakraborty, F. Feller, M. Khalaj

This study identifies ALOX5 as a mediator of chemoresistance in AML by promoting LSC self-renewal through LTB4-BLTR signaling, suggesting ALOX5 inhibition could enhance chemotherapy efficacy.

bioRxiv · Feb 7, 2022 · PreprintCancer Biology

Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole cell mechanics

A. Vahabikashi, S. Sivagurunathan, F. A. S. Nicdao, Y. L. Han, C. Y. Park, X. Wong, J. R. Tran, G. G. Gundersen, K. Reddy, G. G. Luxton, M. Guo, J. J. Fredberg, Y. Zheng, S. A. Adam, R. D. Goldman

This study shows that different nuclear lamin isoforms modulate cell and nuclear mechanics by affecting LINC complex stability and heterochromatin structure in mouse embryonic fibroblasts.

bioRxiv · May 12, 2021Biophysics

Stiffness Regulates Intestinal Stem Cell Fate

S. He, L. Peng, W. Kang, P. Cheung, T. Xu, M. Mana, C. Y. Park, H. Wang, S. Imada, J. O. Russell, J. Wang, R. Wang, Z. Zhou, K. Chetal, E. Stas, , N. Saeidi

This study shows that matrix stiffness affects intestinal stem cell fate by reducing Lgr5high ISCs and promoting differentiation into goblet cells, mediated by YAP nuclear translocation.

bioRxiv · Mar 15, 2021Cell Biology

Newly developed silicone airway stent (GINA stent): Mechanical characteristics and performance evaluation in pigs

H. S. Jung, G. Chae, J. H. Kim, S. Bae, C. Y. Park, S. Lim, S. E. Park, M. S. Jung, J. I. Park, Y. J. Lee, S. K. Kang, D. H. Kim, Y. Lee, T. Lee

The paper evaluates a new silicone airway stent (GINA stent) in pigs, showing improved mechanical properties and comparable performance to the Dumon stent.

bioRxiv · Oct 24, 2020Physiology

Epithelial layer unjamming shifts energy metabolism toward glycolysis

S. J. DeCamp, V. M. K. Tsuda, J. Ferruzzi, S. A. Koehler, D. Roblyer, J. T. Giblin, M. H. Zaman, S. T. Weiss, M. DeMarzio, C. Y. Park, N. C. Ogassavara, J. A. Mitchel, J. P. Butler, J. J. Fredberg

The paper shows that during epithelial layer unjamming, cells shift their metabolism toward glycolysis, even in regions without visible morphological changes.

bioRxiv · Jun 30, 2020Biophysics

Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate

C. Iserman, C. A. Roden, M. Boerneke, R. Sealfon, G. McLaughlin, I. Jungreis, C. Y. Park, A. Boppana, E. Fritch, Y. Hou, C. Theesfeld, O. Troyanskaya, R. S. G. Baric, T. P. Sheahan, K. Weeks, A. Gladfelter

This study shows SARS-CoV-2 N-protein forms liquid-liquid phase separation with specific viral RNA sequences, which is temperature-sensitive and can be modulated by small molecules, offering potential for antiviral drug development.

bioRxiv · Jun 11, 2020 · PreprintBiochemistry

Although host-related factors are important for the formation of gut microbiota, environmental factors cannot be ignored

Y. Jung, D. Kerfahi, H. Q. Pham, H. Son, J. C. Ibal, M.-K. Park, Y.-J. Park, C. E. Park, S.-D. Choi, Y. Jo, M.-C. Kim, M. J. Kim, G. U. Kang, H. W. Jo, H. Yun, , J.-H. Shin

This study compares host-related factors and environmental factors in shaping gut microbiota using fecal samples from naval trainees and healthy individuals, finding host factors more influential.

bioRxiv · Feb 3, 2020 · PreprintMicrobiology

The tumor suppressor p53 promotes carcinoma invasion and collective cellular migration

S. HE, C. V. Carman, J. H. Lee, B. Lan, S. Koehler, L. Atia, C. Y. Park, J. H. Kim, J. A. Mitchel, J.-A. Park, J. P. Butler, S. W. Lee, J. Fredberg

This study shows that p53 loss decreases single-cell motility and invasion in 2-D and 3-D assays, but promotes collective cellular migration in spheroids.

bioRxiv · Jul 30, 2018Cancer Biology

Identification and characterization of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

E. K. O'Shea, Z. Yu, L. E. Surface, C. Y. Park, M. A. Horlbeck, G. A. Wyant, M. Abu-Remaileh, T. R. Peterson, D. M. Sabatini, J. S. Weissman

The paper identifies SLC37A3 as a transporter required for nitrogen-containing bisphosphonates (N-BPs) to enter the cytosol, revealing their mechanism of action.

bioRxiv · Mar 27, 2018Biochemistry