S. Chakraborty

Persistence of florpyrauxifen-benzyl in sediments following application to a large oligotrophic lake to control Eurasian watermilfoil

This study evaluates the persistence of florpyrauxifen-benzyl in sediments of Lake George, finding it persists for at least one year, exceeding toxicity thresholds for aquatic organisms.

Impaired Barrier Integrity of the Skeletal Muscle Vascular Endothelium Drives Progression of Cancer Cachexia

This study identifies impaired vascular endothelial integrity in skeletal muscle as a driver of cancer cachexia and shows that restoring endothelial PGC1 can prevent muscle loss.

H2 consumption by acetogenic bacteria follows first-order kinetics

This study measures H2 consumption rates in three acetogenic bacteria and finds they follow first-order kinetics, contradicting previous assumptions of Monod kinetics.

Identification of new markers of angiogenic sprouting using transcriptomics: New role for RND3

The paper identifies a 39-gene signature associated with endothelial cell sprout initiation and reveals a new role for RND3 in filopodial extension during angiogenesis.

Bi-directional allosteric pathway in NMDA receptor activation and modulation

This study identifies a bidirectional allosteric pathway between the extracellular and transmembrane domains of NMDA receptors, revealing how conformational changes in one domain influence the other.

Evidence for intrinsic DNA dynamics and deformability in damage sensing by the Rad4/XPC nucleotide excision repair complex

The paper investigates DNA dynamics and deformability in Rad4/XPC damage sensing using T-jump and FRET techniques, showing rapid fluctuations and unwound/bent conformations at lesion sites.

Thermal tolerance of mosquito eggs is associated with urban adaptation and human interactions

This study examines the thermotolerance of mosquito eggs and adults from Aedes species, finding that human-associated lineages have higher egg viability under high-temperature stress.

Intra-species quantification reveals differences in activity and sleep levels in the yellow fever mosquito, Aedes aegypti

This study compares activity and sleep levels across 17 Ae. aegypti lines, finding population differences linked to host preference, ancestry, and human population density.

Aedes albopictus colonies from different geographic origins differ in their sleep and activity levels but not in the time of peak activity

This study compares sleep and activity patterns of Aedes albopictus mosquito strains from different geographic origins, finding heritable differences in activity levels but not peak activity times.

O6-Alkylguanine-DNA Alkyltransferase Maintains Genomic Integrity During Peroxynitrite-Mediated DNA Damage by Forming DNA-Protein Crosslinks

This study identifies hAGT as a dual-function protein that repairs DNA damage and forms DNA-protein crosslinks to protect against peroxynitrite-induced genomic instability.

RomX, a novel prokaryotic regulator, links the response receiver domain of RomR with GTP-bound MglA for establishing Myxococcus xanthus polarity

This study determines the crystal structure of RomX, a novel prokaryotic regulator, and shows it interacts with MglA-GTP and RomR-REC domains to regulate MglA localization in Myxococcus xanthus.

S-nitrosylation of EZH2 at C329 and C700 interplay with PRC2 complex assembly, methyltransferase activity, and EZH2 stability to regulate endothelial functions

ALTering cancer by triggering telomere replication stress through the stabilization of promoter G-quadruplex in SMARCAL1

This study shows that stabilizing G-quadruplex in SMARCAL1 promoter reduces its expression, increases replication stress, and promotes DNA damage in ALT-positive cancer cells, suggesting G4 stabilizers as potential therapeutics.

PTBP2 promotes cell survival and autophagy in Chronic Myeloid Leukemia by stabilizing BNIP3

This study shows PTBP2 stabilizes BNIP3 to promote cell survival and autophagy in CML, enhancing tumor formation and imatinib resistance.

Curtailed CaSR expression in peripheral blood mononuclear cells is associated with hypertension

The paper investigates reduced CaSR expression in hypertensive models and links it to impaired NO production and altered Ca2+ dynamics.

Fermented polyherbal formulation restored ricinoleic acid-induced diarrhea in Sprague Dawley rats and exhibited in vitro antibacterial effect on multiple antibiotics resistant gastric pathogens

This paper evaluates a polyherbal formulation AP-01 for treating ricinoleic acid-induced diarrhea in rats and demonstrates its in vitro antibacterial activity against antibiotic-resistant gastric pathogens.

Fermented polyherbal formulation ameliorates the severity of acute multiple - antibiotics - resistant Pseudomonas aeruginosa infected burn wound in rat burn model

This paper evaluates a fermented polyherbal formulation's efficacy in reducing burn wound severity caused by multiple-antibiotic-resistant Pseudomonas aeruginosa in a rat model.

Ants get stuck in traffic jams and resolve them by making adaptive decisions

This study examines ant traffic dynamics during nest relocation, finding that narrow paths cause frequent jams resolved by adaptive decisions from returning leaders.

A microfluidic model of colonocyte-microbiota interaction mimicking the colorectal cancer microenvironment

The paper develops a microfluidic model to study interactions between colonocytes, microbiota, and Fusobacterium nucleatum in a colorectal cancer microenvironment, showing altered gene expression and microbiota composition.

Rapid mode switching facilitates the growth of Trichodesmium: A model analysis.

This study develops a metabolic model of Trichodesmium showing that rapid switching between photosynthetic and non-photosynthetic states enhances growth by improving metabolic efficiency.

The Single-Cell Transcriptome Program of Nodule Development Cellular Lineages in Medicago truncatula

The paper characterizes single-cell transcriptomes during Medicago truncatula nodule development, revealing dynamic changes in auxin and cytokinin signaling pathways across cell lineages.

Single-cell RNA sequencing identifies response of renal lymphatic endothelial cells to acute kidney injury

This study uses single-cell RNA sequencing to characterize renal lymphatic endothelial cells' response to acute kidney injury and identifies gene expression changes across different injury models.

Regulation of shelterin proteins TERF2IP and TRF2 by H3K4me3-p65 axis drives hyperglycemia dependent endothelial senescence

This study shows hyperglycemia increases TERF2IP and TRF2 via H3K4me3-p65 axis, driving endothelial senescence through p53 and p21 upregulation.

Dynamics of a Lipid Vesicle across a Microfluidic Constriction: How does the Fluidity of the Encapsulation and its Micro-EnvironmentMatter?

This paper quantitatively examines how lipid vesicle membrane fluidity and initial shape affect their morphological transitions through a microfluidic constriction, revealing nonlinear dynamics and potential implications for disease detection.

Methotrexate-modulated talin-dynamics drives cellular mechanical phenotypes via YAP signalling

This study shows methotrexate modulates talin dynamics, affecting YAP signaling and cancer cell mechanical properties through focal adhesion changes.

GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior

This study shows GD2 and its biosynthetic enzyme GD3S promote prostate cancer tumorigenesis by maintaining cancer stem cells and EMT markers.

Force-regulated chaperone activity of BiP/ERdj3 is opposite to their homologs DnaK/DnaJ: explained by strain energy

This study compares the force-regulated chaperone activity of tunnel-associated BiP/ERdj3 and their cytoplasmic homologs DnaK/DnaJ, revealing that BiP/ERdj3 act as foldases under force while DnaK/DnaJ act as holdases.

Mechanism of GTPase activation of a prokaryotic small Ras-like GTPase MglA by an asymmetrically interacting MglB dimer

This study investigates how the asymmetric interaction of MglB dimer regulates GEF and GAP activities of MglA, revealing an allosteric mechanism for GEF action.

Toxic metal uptake by oyster mushrooms grown in sugarcane bagasse

This study investigates metal uptake by oyster mushrooms grown on sugarcane bagasse, finding biomagnification of heavy metals in mushrooms compared to the substrate.

Development and qualification of a high-yield recombinant human Erythropoietin biosimilar

This paper develops and characterizes a high-yield biosimilar of recombinant human erythropoietin (rhEPO) that meets regulatory requirements and offers a cost-effective alternative.