Caspase-2 kills cells with extra centrosomes
D. Rizzotto, V. Vigorito, P. Rieder, F. Gallob, G. M. Moretta, C. Soratroi, J. Riley, F. Bellutti, S. Li Veli, A. Mattivi, M. Lohmueller, S. Herzog, B. C. Bornhauser, E. D. Jacotot, A. Villunger, L. L. Fava
The paper shows that caspase-2 triggers apoptosis in cells with extra centrosomes, preventing polyploidization through mitochondrial pathways.
bioRxiv · Feb 13, 2024Cell Biology