Author

E. D. Jacotot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Mattivi· 1 shared A. Villunger· 1 shared b. Brugg· 1 shared B. C. Bornhauser· 1 shared C. El Amri· 1 shared C. Soratroi· 1 shared D. Rizzotto· 1 shared E. Bosc· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

A. Mattivi

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Caspase-2 kills cells with extra centrosomes

D. Rizzotto, V. Vigorito, P. Rieder, F. Gallob, G. M. Moretta, C. Soratroi, J. Riley, F. Bellutti, S. Li Veli, A. Mattivi, M. Lohmueller, S. Herzog, B. C. Bornhauser, E. D. Jacotot, A. Villunger, L. L. Fava

The paper shows that caspase-2 triggers apoptosis in cells with extra centrosomes, preventing polyploidization through mitochondrial pathways.

bioRxiv · Feb 13, 2024Cell Biology

Genuine Selective Caspase-2 Inhibition with new Irreversible Small Peptidomimetics

E. Bosc, J. Anastasie, F. Soualmia, P. Coric, J. Y. Kim, G. Lacin, E. Duplus, P. Tixador, b. Brugg, M. Reboud-Ravaux, S. Bouaziz, M. Karin, C. El Amri, E. D. Jacotot

This paper develops and tests new irreversible peptidomimetics that selectively inhibit Caspase-2, showing efficacy in preventing cell death and synapse loss in disease models.

bioRxiv · Dec 13, 2021Pharmacology & Toxicology