A. Villunger

Exact centriole counts are critical for B cell development but not function

The paper shows that precise centriole counts are essential for B cell development but not for immune function.

Caspase-2 kills cells with extra centrosomes

The paper shows that caspase-2 triggers apoptosis in cells with extra centrosomes, preventing polyploidization through mitochondrial pathways.

Chronic deregulation of the spindle assembly checkpoint triggers myelosuppression and gastrointestinal atrophy

The paper investigates the effects of chronic SAC activation in mice, finding it causes bone marrow aplasia and intestinal atrophy, with BIM playing a critical role in gastrointestinal cell death.

The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression

This study shows that miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression, leading to increased pro-B cell proliferation.

The BH3-only protein NOXA serves as an independent predictor of breast cancer patient survival and defines susceptibility to microtubule targeting agents

This study identifies NOXA as an independent prognostic marker for breast cancer survival and shows its role in predicting response to microtubule-targeting agents.

PIDDosome-induced p53-activation for ploidy restriction facilitates hepatocarcinogenesis

This study shows that PIDDosome-mediated ploidy restriction prevents hepatocellular carcinoma by reducing tumor burden and that low ploidy predicts poor survival in HCC patients.