Author

F. Gielkens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

C. Ottmann· 1 shared D. Macdonald· 1 shared D. Thomas· 1 shared G. Carlile· 1 shared H. Thomas· 1 shared L. Brunsveld· 1 shared L. M. Stevers· 1 shared L. Richard· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

C. Ottmann

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1 paper

Recent·Most cited

Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR

L. M. Stevers, M. Wolter, G. Carlile, D. Macdonald, L. Richard, F. Gielkens, D. Thomas, S. K. Chakka, M. L. Peterson, H. Thomas, L. Brunsveld, C. Ottmann

This paper identifies a macrocycle that stabilizes the 14-3-3/CFTR complex, enhancing CFTR membrane localization and activity, particularly for the F508del mutation.

bioRxiv · Jan 3, 2022Biochemistry