M. Wolter

Diet-driven differential response of Akkermansia muciniphila modulates pathogen susceptibility

This study shows that Akkermansia muciniphila increases susceptibility to a gut pathogen under fiber-deprived conditions but reduces pathogen load on a fiber-sufficient diet.

Opposing diet, microbiome and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host

The paper shows that low dietary fiber promotes colitis in genetically susceptible mice by eroding mucus, while a fiber-free diet increases anti-inflammatory metabolites, highlighting microbial function over taxa in IBD regulation.

Mucin-degrading gut bacteria promote anti-parasitic immunity

This study shows that mucin-degrading gut bacteria influence anti-parasitic immunity by modulating host immune responses, with dietary fiber affecting this interaction.

Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR

This paper identifies a macrocycle that stabilizes the 14-3-3/CFTR complex, enhancing CFTR membrane localization and activity, particularly for the F508del mutation.

Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study

The paper investigates the structural and biophysical interactions between 14-3-3 proteins and hDMX/hDM2, identifying key phosphosites that enable high-affinity binding.

Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen Citrobacter rodentium

This study shows that a low-fiber diet in SPF mice increases susceptibility to Citrobacter rodentium by altering gut microbiota and reducing mucosal barrier integrity.

Dietary modulation alters susceptibility to Listeria monocytogenes and Salmonella typhimurium in a gut microbiota-independent manner

This study shows that a low-fiber diet reduces susceptibility to Listeria monocytogenes and Salmonella typhimurium in a microbiota-independent manner in gnotobiotic mice.