D. Macdonald

Screening the human miRNA interactome reveals coordinated upregulation in melanoma, adding bidirectional regulation to miRNA networks.

The paper identifies miRNAs that upregulate CD98hc and ST3GAL1/ST3GAL2 in melanoma, revealing a bidirectional regulatory mechanism in miRNA networks.

miRNA upregulate protein and glycan expression via direct activation in proliferating cells

The paper shows miRNA can directly upregulate protein and glycan expression in proliferating cells, challenging the dominant view of miRNA repression.

Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR

This paper identifies a macrocycle that stabilizes the 14-3-3/CFTR complex, enhancing CFTR membrane localization and activity, particularly for the F508del mutation.

Using very high-resolution satellite imagery and deep learning to detect and count African elephants in heterogeneous landscapes

This study uses deep learning and high-resolution satellite imagery to detect and count African elephants in heterogeneous landscapes, achieving accuracy comparable to human detection.

Estimating the density of small population of leopard Panthera pardus using multi-session photographic-sampling data

The paper estimates leopard population density in central Iran using multi-session camera trap data and SECR modeling, finding low densities and seasonal/sexual movement patterns.

Human IL-2 receptor β mutations associated with defects in immunity and peripheral tolerance

This study identifies IL-2Rβ gene mutations causing immune and tolerance defects, showing variable expression impacts on T and NK cells and informing IL-2-based therapies.