Chronic IL-1-induced DNA double-strand break response in hippocampal neurons drives cognitive deficits
M. Belloy, B. A. Schmitt, F. H. Marty, C. Paut, E. Bassot-Parra, A. Aida, M. Alis, R. Ecalard, R. Boursereau, D. Gonzalez-Dunia, N. Blanchard, E. Suberbielle
This study shows chronic IL-1 signaling in hippocampal neurons causes DNA double-strand breaks, leading to cognitive deficits in mice infected with Toxoplasma gondii.
bioRxiv · Feb 3, 2024 · PreprintAnimal Behavior & Cognition