N. Blanchard

CD4+ Trm sustain the chronic phase of auto-immune neuroinflammatory disease

This study identifies CD4+ Trm cells in the CNS of PMS patients and EAE models, showing their role in sustaining chronic inflammation and suggesting targeting them for new therapies.

Protective function and differentiation cues of brain-resident CD8+ T cells during immune surveillance of chronic latent Toxoplasma gondii infection

This study identifies the protective functions and differentiation cues of brain-resident CD8+ T cells during chronic Toxoplasma gondii infection using a mouse model and single-cell transcriptomics.

Chronic IL-1-induced DNA double-strand break response in hippocampal neurons drives cognitive deficits

This study shows chronic IL-1 signaling in hippocampal neurons causes DNA double-strand breaks, leading to cognitive deficits in mice infected with Toxoplasma gondii.

Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice

This study shows that regulatory T cells modulate basal somatic sensitivity in mice through enkephalin production, with Penk expression regulated by TNF receptor family and Batf.

The apicoplast is important for the viability and persistence of Toxoplasma gondii bradyzoites

This study shows that targeting the apicoplast in Toxoplasma gondii bradyzoites reduces their viability, suggesting it as a potential therapeutic target for chronic infections.

A common mechanism of Sec61 translocon inhibition by small molecules

This study identifies a common binding site for diverse Sec61 inhibitors and shows how they stabilize the plug domain to block protein translocation.

A virus hosted in malaria-infected blood protects against T cell-mediated inflammatory diseases by impairing DC function in a type I IFN-dependent manner

This study identifies an RNA virus co-hosted in malaria parasites that protects against T cell-mediated inflammatory diseases by impairing dendritic cell function through type I IFN signaling.