Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome
F. Cao, R. Deliz-Aguirre, F. H. U. Gerpott, E. Ziska, M. J. Taylor
The paper shows that Myddosome clustering in IL-1R signaling regulates NF-kB activation by forming a signalosome that enhances TRAF6 and LUBAC recruitment.
bioRxiv · Jan 6, 2023Cell Biology