M. J. Taylor

IRAK4 autophosphorylation controls inflammatory signaling by activating IRAK oligomerization

This study shows IRAK4 auto-phosphorylation activates IRAK oligomerization, controlling inflammatory signaling by promoting DD domain assembly and downstream IL-1 signaling.

An optogenetic method for the controlled release of single molecules

This paper develops an optogenetic method to release single molecules in live cells, enabling controlled delivery of functional proteins and reconstitution of cellular functions at the single molecule level.

Characterizing Subcortical Structural Heterogeneity in Autism

This study examines subcortical structural differences in autism using MRI data, finding localized shape variations rather than volumetric differences, with age-related patterns observed.

A dirofilariasis mouse model for heartworm preclinical research

This paper establishes a mouse model for heartworm drug screening, showing it can effectively assess drug efficacy against D. immitis larvae.

Fungal organic acid uptake of mineral derived K is dependent on distance from carbon hotspot

This study visualizes fungal organic acid-mediated uptake of mineral-derived potassium by showing acid distribution and K+ transport in soil micromodels.

Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome

The paper shows that Myddosome clustering in IL-1R signaling regulates NF-kB activation by forming a signalosome that enhances TRAF6 and LUBAC recruitment.

The role of antifreeze glycopeptides (AFGP) and polyvinyl alcohol/polyglycerol (X/Z-1000) cocktails as ice modulators during partial freezing of rat livers.

This paper evaluates the effects of AFGP and X/Z-1000 ice modulators on the viability and structure of partially frozen rat livers, finding varying impacts on ATP levels, edema, and endothelial damage.

Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites - Trichuris muris, Brugia malayi, Heligmosomoides polygyrus and Schistosoma mansoni

The paper investigates the structure-activity relationship of dihydrobenzoxazepinone (DHB) compounds against various parasitic nematodes and trematodes, identifying key structural features for anthelmintic activity.

On demand MyD88 oligomerization is controlled by IRAK4 during Myddosome signaling

This study investigates how MyD88 oligomerization is regulated by IRAK4 during Myddosome signaling, revealing that oligomer size acts as a threshold for downstream signaling.

Early life maturation of human visual system white matter is altered by monocular enucleation

This study examines structural brain changes in children who underwent monocular enucleation before age 3, finding altered white matter microstructure in visual pathways by ages 8-12.

T cell co-stimulatory receptor CD28 is a primary target for PD-1-mediated inhibition

This study shows PD-1 inhibits T cell activation by preferentially dephosphorylating CD28 over TCR, revealing CD28 as a primary target for PD-1-mediated suppression.

A DNA-based T cell receptor reveals a role for receptor clustering in ligand discrimination

This study uses DNA-based T cell receptors to show that receptor clustering enhances ligand discrimination by enabling kinetic proofreading.