E. Ziska

Bottom-up reconstruction of functional Death Domain Signalosomes reveals a requirement for polymer stability and avidity

The paper constructs a synthetic signalosome using Death Domains and shows that its function depends on polymer stability and avidity, demonstrating these properties are tunable and not restricted to specific motifs.

IRAK4 autophosphorylation controls inflammatory signaling by activating IRAK oligomerization

This study shows IRAK4 auto-phosphorylation activates IRAK oligomerization, controlling inflammatory signaling by promoting DD domain assembly and downstream IL-1 signaling.

Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome

The paper shows that Myddosome clustering in IL-1R signaling regulates NF-kB activation by forming a signalosome that enhances TRAF6 and LUBAC recruitment.

On demand MyD88 oligomerization is controlled by IRAK4 during Myddosome signaling

This study investigates how MyD88 oligomerization is regulated by IRAK4 during Myddosome signaling, revealing that oligomer size acts as a threshold for downstream signaling.