Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficiency and may affect wound healing between old individuals
S. Mahmoudi, E. Mancini, A. Moore, L. Xu, F. Jahanbani, K. Hebestreit, R. Srinivasan, X. Li, K. Devarajan, L. Prelot, C. E. Ang, Y. Shibuya, B. A. Benayoun, A. L. S. Chang, M. Wernig, , A. Brunet
This study shows that old fibroblasts secrete inflammatory cytokines, leading to variability in reprogramming efficiency and affecting wound healing in older individuals.
bioRxiv · Oct 19, 2018 · PreprintCell Biology