Clonal replacement of tumor-specific T cells following PD-1 blockade
K. E. Yost, A. T. Satpathy, D. K. Wells, Y. Qi, C. Wang, R. Kageyama, K. McNamara, J. M. Granja, K. Y. Sarin, R. A. Brown, R. K. Gupta, C. Curtis, S. L. Bucktrout, M. M. Davis, A. L. S. Chang, H. Y. Chang
This study tracks T cell clonal dynamics before and after PD-1 blockade in cancer patients, finding that new T cell clones, not pre-existing ones, expand in response to treatment.
bioRxiv · May 24, 2019Immunology