R. Srinivasan

Mutational analysis of the F plasmid partitioning protein ParA reveals novel residues required for oligomerisation and plasmid maintenance

This study identifies mutations in ParA that disrupt polymerization and plasmid maintenance, highlighting the role of ParA oligomerization in plasmid partitioning.

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

Impaired embryo sac cellularization by PMEI gene mutation affects gamete specification and twin plants in Arabidopsis

This study shows that PMEI gene mutation in Arabidopsis disrupts embryo sac cellularization, leading to multiple egg cells and twin embryos.

An amphipathic helix facilitates direct membrane binding of Mycoplasma FtsZ

This study identifies a novel amphipathic helix in mycoplasma FtsZ that enables direct membrane binding, offering insights into Z-ring constriction in cell wall-less bacteria.

Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents

The paper develops selective Aurora A-TPX2 inhibitors that show in vivo efficacy and synergy with paclitaxel in pancreatic cancer.

Constitutive protein degradation induces acute cell death via proteolysis products

This study shows proteasome-generated peptides from degraded proteins induce cell death by neutralizing IAPs, explaining the efficacy of proteolysis-modulating drugs like thalidomide analogs and bortezomib.

Dynamics of interdomain rotation facilitates FtsZ filament assembly

This study investigates FtsZ assembly dynamics by analyzing SmFtsZ from Spiroplasma melliferum, showing that interdomain rotation is a rate-limiting step in polymerization.

A salt bridge-mediated resistance mechanism to FtsZ inhibitor PC190723 revealed by a cell-based screen

This paper develops a cell-based assay to screen for FtsZ inhibitors and identifies a salt bridge-mediated resistance mechanism to PC190723 in Helicobacter pylori FtsZ.

Filament dynamics driven by ATP hydrolysis modulates membrane binding of the bacterial actin MreB

This study shows that ATP hydrolysis modulates MreB filament dynamics and membrane binding, affecting filament length, bundling, and curvature-dependent orientation.

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

The paper identifies CAM833, a small-molecule inhibitor of BRCA2-RAD51 interaction, which disrupts RAD51 assembly and enhances DNA damage-induced cell death in BRCA2-wildtype cells.

Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program

The paper identifies a methionine-induced mechanism where Ppm1-mediated PP2A methylation stabilizes Gcn4, enabling anabolic growth programs.

LRRK2 regulates innate immune responses and neuroinflammation during Mycobacterium tuberculosis infection

This study shows LRRK2 regulates immune responses and neuroinflammation during Mycobacterium tuberculosis infection, linking it to neurodegenerative disease mechanisms.

Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficiency and may affect wound healing between old individuals

This study shows that old fibroblasts secrete inflammatory cytokines, leading to variability in reprogramming efficiency and affecting wound healing in older individuals.