A non-canonical lipid droplet metabolism regulates the conversion of alpha-Synuclein to proteolytic resistant forms in neurons of a Drosophila model of Parkinson disease
V. Girard, F. Jollivet, O. Knittelfelder, J.-N. Arsac, G. Chatelain, D. Van den Brink, T. Baron, A. Shevchenko, N. Davoust-Nataf, B. Mollereau
This study shows that lipid droplet proteins interact with alpha-synuclein in Drosophila neurons, promoting its resistance to proteolysis and aggregation, suggesting a role for non-canonical lipid metabolism in Parkinson's disease.
bioRxiv · Sep 16, 2020 · PreprintCell Biology