A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients
G. Massacci, V. Venafra, S. Latini, V. Bica, G. M. Pugliese, F. Klingelhuber, N. Krahmer, T. Fischer, D. Mougiakakos, M. Boettcher, L. Perfetto, F. Sacco
The paper identifies the WEE1-CDK1 axis as a key driver of TKI resistance in FLT3-ITD positive AML and suggests combination therapy as a potential treatment.
bioRxiv · May 16, 2022Cancer Biology