Author

D. Mougiakakos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

F. Sacco· 2 shared G. M. Pugliese· 2 shared G. Massacci· 2 shared L. Perfetto· 2 shared M. Boettcher· 2 shared S. Latini· 2 shared T. Fischer· 2 shared V. Bica· 2 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

F. Sacco

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Unveiling the signaling network of FLT3-ITD AML improves drug sensitivity prediction

S. Latini, V. Venafra, G. Massacci, V. Bica, S. Graziosi, G. M. Pugliese, M. Iannuccelli, F. Frioni, G. Minnella, J. D. Marra, P. Chiusolo, G. Pepe, M. Helmer-Citterich, D. Mougiakakos, M. Boettcher, , F. Sacco

This study develops a systems-based strategy to predict drug sensitivity in FLT3-ITD AML by integrating genomic, transcriptomic data with a prior-knowledge signaling network.

bioRxiv · Jun 22, 2023Cancer Biology

A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients

G. Massacci, V. Venafra, S. Latini, V. Bica, G. M. Pugliese, F. Klingelhuber, N. Krahmer, T. Fischer, D. Mougiakakos, M. Boettcher, L. Perfetto, F. Sacco

The paper identifies the WEE1-CDK1 axis as a key driver of TKI resistance in FLT3-ITD positive AML and suggests combination therapy as a potential treatment.

bioRxiv · May 16, 2022Cancer Biology

Mitochondrial function is essential for humoral immunity by controlling flux of the TCA cycle, phosphatidic acid and mTOR activity in B cells

S. Urbanczyk, O. Baris, J. Hofmann, F. Golombek, K. Castiglione, X. Meng, A. Bozec, D. Mougiakakos, S. R. Schulz, W. Schuh, U. Schloetzer-Schrehardt, T. Steinmetz, S. Brodesser, R. J. Wiesner, D. Mielenz

This study shows that mitochondrial function is critical for B cell differentiation into plasma cells by regulating TCA cycle flux, phosphatidic acid levels, and mTOR activity.

bioRxiv · Jan 14, 2021 · PreprintImmunology