Author

M. Boettcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

D. Mougiakakos· 2 shared F. Sacco· 2 shared G. M. Pugliese· 2 shared G. Massacci· 2 shared L. Perfetto· 2 shared S. Latini· 2 shared T. Fischer· 2 shared V. Bica· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

D. Mougiakakos

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Unveiling the signaling network of FLT3-ITD AML improves drug sensitivity prediction

S. Latini, V. Venafra, G. Massacci, V. Bica, S. Graziosi, G. M. Pugliese, M. Iannuccelli, F. Frioni, G. Minnella, J. D. Marra, P. Chiusolo, G. Pepe, M. Helmer-Citterich, D. Mougiakakos, M. Boettcher, , F. Sacco

This study develops a systems-based strategy to predict drug sensitivity in FLT3-ITD AML by integrating genomic, transcriptomic data with a prior-knowledge signaling network.

bioRxiv · Jun 22, 2023Cancer Biology

A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients

G. Massacci, V. Venafra, S. Latini, V. Bica, G. M. Pugliese, F. Klingelhuber, N. Krahmer, T. Fischer, D. Mougiakakos, M. Boettcher, L. Perfetto, F. Sacco

The paper identifies the WEE1-CDK1 axis as a key driver of TKI resistance in FLT3-ITD positive AML and suggests combination therapy as a potential treatment.

bioRxiv · May 16, 2022Cancer Biology

High throughput CRISPR screening identifies genes involved in macrophage viability and inflammatory pathways

S. Covarrubias, A. Vollmers, A. Capili, M. Boettcher, E. K. Robinson, L. O'Briain, C. Vollmers, J. Blau, M. McManus, S. Carpenter

The paper uses CRISPR screening to identify genes essential for macrophage viability and regulators of inflammatory pathways like NF-κB and TNF signaling.

bioRxiv · Oct 17, 2019Immunology

Leukocyte-derived High-mobility group box 1 controls innate immune responses against Listeria monocytogenes.

A. Volmari, K. Foelsch, K. Yan, M. Qi, K. Bartels, S. Kondratowicz, M. Boettcher, M. Nishibori, K. Liu, R. F. Schwabe, A. W. Lohse, S. Huber, H.-W. Mittruecker, P. Huebener

This study shows that HMGB1 from leukocytes is critical for immune responses against Listeria monocytogenes, while hepatocyte HMGB1 is not essential for moderate infections but may contribute to excessive inflammation in severe cases.

bioRxiv · Oct 8, 2019 · PreprintImmunology