Author

G. M. Pugliese

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Assay:DNA methylation· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Franchitto· 3 shared P. Pichierri· 3 shared D. Mougiakakos· 2 shared E. Malacaria· 2 shared F. Sacco· 2 shared G. Massacci· 2 shared L. Perfetto· 2 shared M. Boettcher· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

A. Franchitto

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Author profile →

5 papers

Recent·Most cited

Unveiling the signaling network of FLT3-ITD AML improves drug sensitivity prediction

S. Latini, V. Venafra, G. Massacci, V. Bica, S. Graziosi, G. M. Pugliese, M. Iannuccelli, F. Frioni, G. Minnella, J. D. Marra, P. Chiusolo, G. Pepe, M. Helmer-Citterich, D. Mougiakakos, M. Boettcher, , F. Sacco

This study develops a systems-based strategy to predict drug sensitivity in FLT3-ITD AML by integrating genomic, transcriptomic data with a prior-knowledge signaling network.

bioRxiv · Jun 22, 2023Cancer Biology

Phosphorylation Status Of MUS81 Is A Modifier Of Olaparib Sensitivity In BRCA2-Deficient Cells

F. Blandino, E. Malacaria, C. Figlioli, A. Noto, G. M. Pugliese, A. Franchitto, P. Pichierri

This study shows that phosphorylation status of MUS81 affects PARPi sensitivity in BRCA2-deficient cells by modulating MUS81 activity in different phases of the cell cycle.

bioRxiv · Aug 13, 2022Cell Biology

A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients

G. Massacci, V. Venafra, S. Latini, V. Bica, G. M. Pugliese, F. Klingelhuber, N. Krahmer, T. Fischer, D. Mougiakakos, M. Boettcher, L. Perfetto, F. Sacco

The paper identifies the WEE1-CDK1 axis as a key driver of TKI resistance in FLT3-ITD positive AML and suggests combination therapy as a potential treatment.

bioRxiv · May 16, 2022Cancer Biology

Generation of inducible SMARCAL1 knock-down iPSC to model severe Schimke immune-osseous dysplasia reveals a link between replication stress and altered expression of master differentiation genes

G. M. Pugliese, F. Salaris, V. Palermo, V. Marabitti, N. Morina, A. Rosa, A. Franchitto, P. Pichierri

This study generates SMARCAL1 knock-down iPSCs to model Schimke immune-osseous dysplasia, revealing replication stress and altered gene expression as key factors in disease pathogenesis.

bioRxiv · Feb 10, 2019Cell Biology

Phosphorylation By CK2 Regulates MUS81/EME1 In Mitosis And After Replication Stress

A. Palma, G. M. Pugliese, I. Murfuni, V. Marabitti, E. Malacaria, S. Rinalducci, A. Minoprio, M. Sanchez, F. Mazzei, L. Zolla, A. Franchitto, P. Pichierri

This study shows CK2 phosphorylates MUS81 at Serine 87 in mitosis and under replication stress, promoting its interaction with SLX4 and affecting chromosome stability.

bioRxiv · Mar 7, 2018Cell Biology