Endothelial SHP-1 regulates diabetes-induced abnormal collateral vessel formation and endothelial cell senescence
A. Nadeau, M. Ouellet, R. Beland, C. Mercier, S. Robillard, F. Lizotte, M.-A. Despatis, C. F. Benzinger, P. Geraldes
This paper shows that deleting SHP-1 in endothelial cells improves blood flow and limb function in diabetic mice by reversing senescence and restoring VEGF activity.
bioRxiv · Apr 26, 2024Cell Biology